兔抗KLC1多克隆抗体

Background:

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.

Applications:

ELISA, WB, IHC

Name of antibody:

KLC1

Immunogen:

Fusion protein of human KLC1

Full name:

kinesin light chain 1

Synonyms：

KLC; KNS2; KNS2A

SwissProt:

Q07866

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human cervical cancer and human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

65 kDa

WB Positive control:

Lovo cells

WB Recommended dilution:

200-1000