兔抗DPM1多克隆抗体

Background:

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

DPM1

Immunogen:

Full length fusion protein

Full name:

dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

Synonyms:

MPDS; CDGIE

SwissProt:

O60762

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain

IHC Recommend dilution:

20-100