兔抗GSDMA多克隆抗体

Background:

May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

Applications:

ELISA, WB, IHC

Name of antibody:

GSDMA

Immunogen:

Fusion protein of human GSDMA

Full name:

gasdermin A

Synonyms:

GSDM; FKSG9; GSDM1

SwissProt:

Q96QA5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human ovarian cancer

IHC Recommend dilution:

100-200

WB Predicted band size:

49 kDa

WB Positive control:

LO2 and 293T cell lysates

WB Recommended dilution:

500-2000