兔抗ACER1多克隆抗体

Background:

Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).

Applications:

ELISA, IHC

Name of antibody:

ACER1

Immunogen:

Synthetic peptide of human ACER1

Full name:

alkaline ceramidase 1

Synonyms:

ASAH3; ALKCDase1

SwissProt:

Q8TDN7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human brain

IHC Recommend dilution:

25-100