兔抗CYFIP1多克隆抗体

Background:

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.

Applications:

ELISA, IHC

Name of antibody:

CYFIP1

Immunogen:

Fusion protein of human CYFIP1

Full name:

cytoplasmic FMR1 interacting protein 1

Synonyms:

SHYC; SRA1; SRA-1; P140SRA-1

SwissProt:

Q7L576

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human esophagus cancer

IHC Recommend dilution:

25-100