兔抗DUX4多克隆抗体

Background:

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

DUX4

Immunogen:

Synthetic peptide of human DUX4

Full name:

double homeobox 4

Synonyms:

DUX4L

SwissProt:

Q9UBX2

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer;Human thyroid cancer

IHC Recommend dilution:

20-100