兔抗CTNNA1多克隆抗体

Background:

Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components.

Applications:

ELISA, WB, IHC

Name of antibody:

CTNNA1

Immunogen:

Fusion protein of human CTNNA1

Full name:

Catenin (cadherin-associated protein), alpha 1, 102kDa

Synonyms:

CAP102

SwissProt:

P35221

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

100 kDa

WB Positive control:

A431 cells

WB Recommended dilution:

500-2000