兔抗CD33多克隆抗体

Background:

CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Applications:

ELISA, WB, IHC

Name of antibody:

CD33

Immunogen:

Fusion protein of human CD33

Full name:

CD33 molecule

Synonyms：

p67; SIGLEC3; SIGLEC-3

SwissProt:

P20138

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

40 kDa

WB Positive control:

Hela and NIH/3T3 cells

WB Recommended dilution:

200-1000