兔抗SLIT2多克隆抗体

Background:

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, WB, IHC

Name of antibody:

SLIT2

Immunogen:

Synthetic peptide of human SLIT2

Full name:

slit guidance ligand 2

Synonyms:

SLIL3; Slit-2

SwissProt:

O94813

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and Human colon cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

170 kDa

WB Positive control:

Mouse bladder tissue

WB Recommended dilution:

200-1000