兔抗GFRA1多克隆抗体

Background:

This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Applications:

ELISA, WB, IHC

Name of antibody:

GFRA1

Immunogen:

Synthetic peptide of human GFRA1

Full name:

GDNF family receptor alpha 1

Synonyms:

GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1

SwissProt:

P56159

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain and Human ovarian cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

51 kDa

WB Positive control:

Rat brain tissue lysate

WB Recommended dilution:

500-2000