兔抗TSG101多克隆抗体

Background:

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

Applications:

ELISA, IHC

Name of antibody:

TSG101

Immunogen:

Fusion protein of human TSG101

Full name:

tumor susceptibility 101

Synonyms:

TSG10; VPS23

SwissProt:

Q99816

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human esophagus cancer

IHC Recommend dilution:

20-100