兔抗CTTN(Phospho-Tyr466)多克隆抗体

Background:

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Applications:

WB

Name of antibody:

CTTN (Phospho-Tyr466)

Immunogen:

Synthetic peptide of human CTTN (Phospho-Tyr466)

Full name:

cortactin (Phospho-Tyr466)

Synonyms：

Amplaxin; CTTN; EMS1; SRC8

SwissProt:

Q14247

WB Predicted band size:

85 kDa

WB Positive control:

Jurkat cells treated with H2O2

WB Recommended dilution:

500-1000