兔抗FLT3(Phospho-Tyr842)多克隆抗体

Background:

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor.

Applications:

WB

Name of antibody:

FLT3(Phospho-Tyr842)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 842(S-N-Y(p)-V-V) derived from Human FLT3 .

Full name:

fms-related tyrosine kinase 3

Synonyms：

FLK2; STK1; CD135; FLK-2

SwissProt:

P36888

WB Predicted band size:

113 kDa

WB Positive control:

HepG2 cells lysates treated with EGF

WB Recommended dilution:

500-1000