兔抗CASP3(active)多克隆抗体

Background:

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

Applications:

ELISA, IHC

Name of antibody:

CASP3(active)

Immunogen:

Synthetic peptide of human CASP3

Full name:

caspase 3

Synonyms:

CPP32; SCA-1; CPP32B

SwissProt:

P42574

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

50-100