兔抗HORMAD2多克隆抗体

Background:

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).

Applications:

ELISA, IHC

Name of antibody:

HORMAD2

Immunogen:

Fusion protein of human HORMAD2

Full name:

HORMA domain containing 2

Synonyms:

CT46.2

SwissProt:

Q8N7B1

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human tonsil

IHC Recommend dilution:

50-200