兔抗CHEK1多克隆抗体

Background:

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC2 protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

CHEK1

Immunogen:

Synthetic peptide of human CHEK1

Full name:

checkpoint kinase 1

Synonyms:

CHK1

SwissProt:

O14757

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human colorectal cancer

IHC Recommend dilution:

20-100