兔抗EIF2AK3(Ab-982)多克隆抗体

Background:

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Applications:

WB, IHC

Name of antibody:

EIF2AK3(Ab-982)

Immunogen:

Synthesized non-phosphopeptide derived from human PEK/PERK around the phosphorylation site of threonine 982(R-H-T(p)-G-Q).

Full name:

eukaryotic translation initiation factor 2 alpha kinase 3

Synonyms:

PEK; WRS; PERK

SwissProt:

Q9NZJ5

IHC positive control:

Human colon carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

125 kDa

WB Positive control:

MCF-7 cells lysate

WB Recommended dilution:

500-3000